Selective Impact of ALK and MELK Inhibition on ERα Stability and Cell Proliferation in Cell Lines Representing Distinct Molecular Phenotypes of Breast Cancer

Using classical signal transduction and cell proliferation methods, along with multiple breast cancer cell lines, scientists identified enhanced sensitivity of ERα-positive breast cancer cell lines to anaplastic lymphoma kinase (ALK) and maternal embryonic leucine zipper kinase (MELK) inhibitors, inducing ERα degradation and diminishing proliferation in specific breast cancer subtypes.