Enteric Coronavirus nsp2 Is a Virulence Determinant That Recruits NBR1 for Autophagic Targeting of TBK1 to Diminish the Innate Immune Response

PEDV mutants containing a complete nsp2 deletion was entirely avirulent in vivo, with significantly increased productions of interferon beta and IFN-stimulated genes in various intestinal tissues of challenged newborn piglets.