RUVBL1 Ubiquitination by DTL Promotes RUVBL1/2-β-Catenin-Mediated Transcriptional Regulation of NHEJ Pathway and Enhances Radiation Resistance in Breast Cancer

Investigators revealed that RUVBL1 was excessively expressed in mouse models undergoing radiotherapy, which is considered a murine spontaneous breast-tumor model. RUVBL1 enhanced DNA damage repair and radioresistance in breast cancer cells both in vitro and in vivo.