Self-Regulating CAR-T Cells Modulate Cytokine Release Syndrome in Adoptive T Cell Therapy

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With a humanized NSG-SGM3 mouse model, investigators showed reduced CRS-related toxicity in mice treated with CAR-T cells secreting tocilizumab-derived single-chain variable fragment, yielding a safety profile superior to that of single-dose systemic tocilizumab administration.
[Journal Of Experimental Medicine]
Abstract