A Glycolytic Metabolite Bypasses “Two-Hit” Tumor Suppression by BRCA2

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The authors reported that the glycolytic metabolite methylglyoxal transiently bypasses Knudson’s paradigm by inactivating the breast cancer suppressor protein BRCA2 to elicit a cancer-associated, mutational single-base substitution signature in nonmalignant mammary cells or patient-derived organoids.
[Cell]
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