A Glycolytic Metabolite Bypasses “Two-Hit” Tumor Suppression by BRCA2

The authors reported that the glycolytic metabolite methylglyoxal transiently bypasses Knudson’s paradigm by inactivating the breast cancer suppressor protein BRCA2 to elicit a cancer-associated, mutational single-base substitution signature in nonmalignant mammary cells or patient-derived organoids.