Efficient CAR T Cell Targeting of the CA125 Extracellular Repeat Domain of MUC16

Researchers tested a series of antibodies raised against the CA125 extracellular repeat domain of MUC16 and adapted them to the CAR format. Comparisons between these candidates, and against an existing CAR targeting the MUC16 ectodomain, identified K101 as having high potency and specificity.