Development of a Compact Bidirectional Promoter-Driven Dual Chimeric Antigen Receptor (CAR) Construct Targeting CD19 and CD20 in the Sleeping Beauty (SB) Transposon System

The authors developed a second-generation CAR directing CD19 and CD20 antigens, incorporating them in a head-to-head orientation from a bidirectional promoter using a single Sleeping Beauty transposon system.