Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy

To understand the importance of endothelial proliferation and migration for the beneficial versus adverse effects of vascular endothelial growth factor B (VEGF-B) in the heart, investigators explored the cardiac effects of autocrine versus paracrine VEGF-B expression in transgenic and gene-transduced mice.