Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression

Scientists identified a subset of myofibroblast cancer-associated fibroblast (CAFs) that were senescent (senCAF) in mouse and human breast tumors. SenCAFs were present in HER2+, ER+, and triple-negative breast cancer and in ductal carcinoma in situ (DCIS) where they predicted tumor recurrence.