A Positive Feedback Inhibition of Isocitrate Dehydrogenase 3β on Paired-Box Gene 6 Promotes Alzheimer-Like Pathology

Scientists reported a substantial decline in isocitrate dehydrogenase 3β (IDH3β) levels, a critical tricarboxylic acid cycle enzyme, in Alzheimer’s disease (AD) patients and AD-transgenic mouse brains.