Betaglycan Sustains HGF/Met Signaling in Lung Cancer and Endothelial Cells Promoting Cell Migration and Tumor Growth

Scientists found that HGF/Met promoted lung cancer and endothelial cells migration via PI3K and mTOR. This effect was enhanced by recombinant soluble betaglycan via a mechanism attributable to its glycosaminoglycan chains, as a mutant without them did not modulate HGF effects.