Antibody Drug Conjugate Sacituzumab Govitecan Enables a Sequential TOP1/PARP Inhibitor Cancer Therapy Strategy in Breast Cancer Patients

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Scientists assessed proof-of-mechanism and clinical feasibility for Sacituzumab govitecan (SG) and talazoparib employing an innovative sequential dosing schedule. In vitro, sequential SG followed by talazoparib delayed topoisomerase 1 cleavage complex clearance, increased DNA damage and promoted apoptosis.
[Clinical Cancer Research]
Abstract