Inhibiting proBDNF To Mature BDNF Conversion Leads to ASD-Like Phenotypes In Vivo

Researchers generated a knock-in mouse line in which the conversion of pro-brain-derived neurotrophic factor (BDNF) to mature BDNF was attenuated. Mice showed reduced dendritic arborization, altered spines, and impaired synaptic transmission and plasticity in the hippocampus. They also exhibited autism spectrum disorder-like phenotypes, including stereotypical behaviors and deficits in social interaction.