Controlled Human Hookworm Infection Remodels Plasmacytoid Dendritic Cells and Regulatory T Cells Towards Profiles Seen in Natural Infections in Endemic Areas

By leveraging controlled human infection models and high-dimensional immunophenotyping, researchers investigated the immune remodeling following infection with 50 Necator americanus L3 hookworm larvae in four naïve volunteers over two years of follow-up and compared the profiles with naturally infected populations in endemic areas.