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[BioRestorative Therapies, Inc. ] BioRestorative Therapies, Inc. announced that the last patient has been dosed in its fully enrolled Phase II clinical trial evaluating BRTX-100 for the treatment of chronic lumbar disc disease, completing treatment administration in the Company’s lead clinical program.

[TriCelX, Inc.] TriCelX, Inc. has submitted a Phase I/II Investigational New Drug application to the US FDA for XytriX™ — its proprietary allogeneic UC-MSC biotherapeutic, ethically sourced from donated human birth tissue — for adults with confirmed or probable Chronic Traumatic Encephalopathy.

[Neurology] In this randomized, double-blind, placebo-controlled Phase I/II trial, patients with progressive multiple sclerosis enrolled at four Norwegian tertiary hospitals received a single intrathecal injection of autologous bone marrow–derived MSCs in a crossover design.

[Arteriosclerosis Thrombosis and Vascular Biology] This cross-species analysis revealed a conserved mesenchymal cell continuum, spanning contractile smooth muscle cells to extracellular matrix-producing fibroblast-like cells, that was stable across species and vascular beds.

[Signal Transduction and Targeted Therapy] Researchers identified Zinc finger MIZ domain-containing protein 1 (ZMIZ1) as a previously unrecognized transcriptional co-regulator that enforces differentiation blockade in AML from a targeted CRISPR-Cas9 screen.

[Nature Cell Biology] By performing single-cell transplantations of over 1,000 highly purified murine long-term HSCs combined with in-depth phenotyping of their clonal progeny, scientists defined kinetics-based reconstitution parameters which aligned HSCs into a single hierarchical trajectory reflective of functional potency.

[Blood] To understand the connection between chromatin accessibility and GATA1, investigators comprehensively studied erythropoiesis in Stag2∆ mice.

[Nature Cancer] Scientists used a targeted in vivo CRISPR screen to identify nutritional dependencies of systemic and central nervous system acute lymphoblastic leukemia.

[Nucleic Acids Research] The authors identified a conserved set of seven zinc finger protein (ZNF) genes, including ZNF184, that are upregulated in acute lymphoblastic leukemia and exhibit dynamic expression patterns linked to disease progression.

[Nature Communications] Researchers showed that clonal hematopoiesis (CH) co-occurrences are selected for in the aging population and identified CH clones with notable implications for future malignancy risk.

[Clinical Chemistry and Laboratory Medicine] Investigators validated the utility of flow cytometric detection of nPAX5 for the diagnosis of B-lymphoblastic leukemia, potentially enhancing diagnostic efficiency.

[Blood Advances] Scientists reported the outcomes of a multicenter, open-label Phase Ib study of ABBV-744 in patients with myelofibrosis who received ≥1 previous lines of therapy, including a Janus kinase inhibitors.