Newsletters

[American Journal of Respiratory and Critical Care Medicine] Investigators characterized the role of ADAM with Thrombospondin motifs 14 (ADAMTS14) in YAP-mediated fibroblast mechanoactivation and pulmonary fibrosis.

[Signal Transduction and Targeted Therapy] In this study, digital spatial profiling, multiplex immunofluorescence, and clinical data from 52 lung adenocarcinoma patients were integrated to develop organ-specific metastasis risk models, and the molecular mechanisms underlying metastatic organotropism were investigated.

[Cancer Letters] Researchers identified pyruvate carboxylase as a pivotal ferroptosis regulator that is highly expressed in NSCLC tissues and associated with aggressive progression and poor prognosis.

[Oncogene] Scientists revealed that phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) mRNA and protein levels were significantly increased in lung-adenocarcinoma tumor tissues compared to adjacent normal tissues.

[Oncogene] The authors established tyrosine kinase inhibitor (TKI)-resistant variants by integrating cell lines, lung cancer organoids, and in vivo models, revealing the pivotal role of the NF-κB/ALDH1A1 signaling in mediating non-mutational TKI resistance.

[Oncology Reports] M2‑like macrophages, IL‑4/IL‑13‑polarized THP‑1‑derived macrophages, were shown to release exosomes that lung cancer cells effectively internalized. These exosomes markedly enhanced the proliferation, migration, and invasion of lung cancer cells, thereby promoting malignancy.

[Translational Oncology] The authors frame lung cancer stem cells and the tumor immune microenvironment as a reciprocal regulatory network rather than as independent biological compartments.

[Memorial Sloan Kettering Cancer Center] A new drug that treats NSCLC carrying a mutation called a ROS1 fusion has been approved by the US FDA. The drug zidesamtinib (Jideytro) was approved for patients with advanced ROS1-positive NSCLC who have stopped responding to other drugs aimed at ROS1.

[European Heart Journal] Intercellular communication patterns in human plaque microenvironments were mapped to reveal novel targets to prevent atherosclerotic events.

[Molecular Systems Biology] Using imaging mass cytometry, scientists investigated the association between cellular niches and their surrounding matrix environment during allergic airway inflammation in two commonly used in-bred mouse strains.

[ACS Applied Materials & Interfaces] Researchers developed an ECM-inspired dielectric film that enhances energy storage by improving molecular polarization, suppressing charge leakage, and increasing electrical breakdown strength.

[Biomaterials Science] Scientists reported a bioorthogonally reinforced ECM-mimetic granular hydrogel platform assembled from complementary gelatin and hyaluronic acid–derived microparticles that anneal through dynamic hydrazone coupling.