Newsletters

[Centauri Therapeutics Limited] Centauri Therapeutics Limited announced that the Company’s lead clinical candidate in the ABX-01 programme, CTX-187, has received Qualified Infectious Disease Product designation from the US FDA.

[Cocrystal Pharma, Inc.] Cocrystal Pharma, Inc. announced the first subjects have been dosed in a Phase Ib norovirus challenge study to evaluate CDI-988, a direct-acting, oral antiviral, as both a preventive and treatment for norovirus infections.

[Nature] To understand the basis and impact of imprinting by influenza A viruses, scientists characterized the B cell responses of young children after consecutive first infections with divergent H1N1 and H3N2 strains of influenza.

[Clinical Microbiology Reviews] Scientists examine the translational viability of peptide-based antimicrobials and siderophore conjugates—two classes of therapeutics often promoted as next-generation solutions against multidrug-resistant pathogens.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists revealed a critical role for an S2 mutation in destabilizing the spike and attenuated phenotypes of the Mink Cluster 5 SARS-CoV-2 variant in humans.

[PLOS One] Researchers used the rhesus macaque model of acute SARS-CoV-2 infection to investigate the impact of glucocorticoids on host responses and viral control in a setting of mild disease.

[Trends In Parasitology] Helminths have been tested as inflammatory disease therapeutics. The authors focus on immune responses during controlled infections with Trichuris species, Necator americanus, and Schistosoma mansoni.

[Nature Metabolism] Researchers showed that ECM1 is an early regulator of kidney remodelling. Global Ecm1 knockout mice develop spontaneous fibrosis and early death, whereas ECM1 levels markedly increase in biofluids during chronic kidney disease.

[ACS Nano] Investigators proposed an ECM-biomimetic microenvironment-regulating coating, where a polyethylene glycol linker with antifouling effects is used to graft tailored recombinant humanized collagen type I possessing high cell-adhesive activity via an efficient click reaction.

[Advanced Healthcare Materials] Scientists developed a cascade reaction-enhanced sonodynamic therapeutic system that yields highly cytotoxic peroxynitrite (ONOO⁻). The resulting ONOO⁻ activates matrix metalloproteinases to degrade the ECM, thereby enhancing nanoparticle penetration and establishing a self-reinforcing antitumor cycle.

[Lab on a Chip] The authors created a microfluidic chip that recreates an inflammation event and directly isolates neutrophils from a small volume of whole blood using a 3D extracellular matrix.

[International Journal of Cancer] Scientists investigated whether the actin-related protein (Arp) 2/3 complex, a key actin nucleator, is essential for pancreatic ductal adenocarcinoma cells to overcome extracellular matrix stiffness and facilitate migration.