METTL16-SENP3-LTF Axis Confers Ferroptosis Resistance and Facilitates Tumorigenesis in Hepatocellular Carcinoma

The roles of METTL16 on ferroptosis and hepatocellular carcinoma (HCC) development were investigated in multiple cell lines, human HCC organoids, subcutaneous xenografts and MYC/Trp53−/− HCC model in hepatocyte-specific Mettl16 knockout and overexpression mice.