The RNA Helicase DDX21 Activates YAP to Promote Tumorigenesis and Is Transcriptionally Upregulated by β-Catenin in Colorectal Cancer

Scientists showed that DDX21 was a direct transcriptional target gene of β-catenin and mediated the protumorigenic function of β-catenin in colorectal cancer (CRC). Loss of DDX21 led to cytoplasmic translocation and decreased transcriptional activity of YAP and suppressed the proliferation and migration of CRC cells.