Spatially-Resolved Organoid Transfection by Porous Silicon-Mediated Optoporation

Researchers proposed a solution to localized optoporation in 3D systems by demonstrating that porous silicon nanoparticles were a safe and bioresorbable photosensitising nanomaterial capable of spatially-resolved transfection of mRNA in MCF-7 organoids by near-infrared two-photon optoporation.