Integrative Single-Cell Multi-Omics of CD19-CARpos and CARneg T Cells Suggest Drivers of Immunotherapy Response in B Cell Neoplasias

Investigators integrated clonal kinetics with transcriptomic heterogeneity resolved by single-cell omics to interrogate cellular dynamics of non-transduced and transduced T cells, in the infusion product and at the CAR-T cell expansion peak in five B cell acute lymphoblastic leukemia patients treated with CD19 CAR-T cells