In Human CD4⁺ T-Cells, Omeprazole Suppresses Proliferation, Downregulates V-ATPase, and Promotes Differentiation Toward an Autoimmunity-Favoring Phenotype

Triggered by findings indicating a correlation between proton pump inhibitors usage and susceptibility to infectious or autoimmune diseases, investigators studied the impact of a pharmacological concentration of omeprazole on human CD4+ T cells.