NOS Inhibition Sensitizes Metaplastic Breast Cancer to PI3K Inhibition and Taxane Therapy via C-JUN Repression

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Scientists reported that nitric oxide synthase (NOS) blockade potentiated response of human metaplastic breast cancer cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane.
[Nature Communications]
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