Pancreatic Cancer-Derived Extracellular Vesicles Remodel the Tumor Microenvironment and Enhance Chemoresistance by Delivering KRASG12D Protein to Cancer-Associated Fibroblasts

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Researchers detected KRASG12D protein in cancer-associated fibroblasts (CAFs) from clinical samples of PDAC. In vitro experiments demonstrated that KRASG12D protein in CAFs was not expressed from its own mutant gene but was derived from the ingestion of tumor cell-derived extracellular vesicles.
[Molecular Therapy]
AbstractGraphical Abstract