AGER-Dependent Macropinocytosis Drives Resistance to KRAS-G12D–Targeted Therapy in Advanced Pancreatic Cancer

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The authors found that advanced glycosylation end product–specific receptor (AGER) contributed to MRTX1133 resistance in PDAC through modulation of macropinocytosis and glutathione synthesis using patient-derived xenografts and orthotopic and genetically engineered mouse models.
[Science Translational Medicine]
Abstract