Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production

Researchers reported that POU-domain containing family protein POU3F3 was translocated into the nuclei of NSCLC cell lines harboring mutant RAS, where it activated transcription of ATP5PF leading to enhanced NSCLC proliferation and migration.