Neutrophil-Derived Serine Proteases Induce FOXA2-Mediated Autophagy Dysfunction and Exacerbate Colitis-Associated Carcinogenesis via F2RL1/Protease-Activated Receptor 2

Researchers showed that F2R like trypsin receptor 1 (F2rl1)/Par2 deficiency aggravated azoxymethane-dextran sulfate sodium-induced colitis-associated colorectal cancer based on tumor number and burden, and promoted autophagy dysfunction characterized by SQSTM1/p62 accumulation.