G Protein-Coupled Estrogen Receptor Reduces the Breast Cancer Cell Survival by Regulating the IRE1α/Mir-17-5p/ TXNIP Pathway

Investigators explored whether G protein-coupled estrogen receptor 1 can induce the UPR response in the SKBR3 cell line through estrogen receptor and inositol-requiring enzyme 1 alpha activation, and to assess whether this response leads to cell survival or cell death.