Lactate Dehydrogenase A-Coupled NAD⁺ Regeneration Is Critical for Acute Myeloid Leukemia Cell Survival

Scientists demonstrated that AML cells critically depend on lactate dehydrogenase A (LDHA) to maintain an adequate NAD⁺/NADH balance in support of their abnormal glycolytic activity and biosynthetic demands, which cannot be compensated for by other cellular NAD⁺ recycling systems.