A Genome-Wide CRISPR Screen Unveils the Endosomal Maturation Protein WDR91 As a Promoter of Productive ASO Activity in Melanoma

Using a CRISPR screen, scientists investigated intracellular proteins involved in antisense oligonucleotides (ASOs) efficiency using a whole genome approach and identified several potential regulators which could significantly impact ASOs potency in melanoma cells.