Mitochondrial 1-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis

Researchers provided insights into the critical role of mitochondrial 1-carbon metabolism and MTHFD2 in governing the differentiation of CD34-lineage cells into Tfh cells, which contributed to tertiary lymphoid organ formation in transplant vasculopathy, offering potential therapeutic targets to enhance transplant outcomes.