Establishment and Validation of a C57BL/6J Mouse Model for Melasma

Researchers established a melasma-like model in C57BL/6J mice. Histopathological analysis revealed an accumulation of melanin granules in the epidermis and superficial dermis, elevated levels of tyrosinase in both skin and plasma, systemic oxidative stress imbalance, and reduced autophagic activity in the lesional skin.