Activation of T Cell-Intrinsic P53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherapy

Researchers show that activation of T cell-intrinsic p53 via carboxyl-terminal domain acetylation during immunotherapy activates the IFN-γ pathway, promotes CD8⁺ T cell infiltration, and elicits CD8⁺ T cell-dependent antitumor immunity.