NewslettersESC & iPSC News A Conserved Function of EZH2-PRC2 in Repression of Primitive Endoderm Fate in Mouse and Human Pluripotent Cells By Noshin Noorjahan - November 12, 2025 0 44 Investigators revealed that enhancer of zeste homolog 2 (EZH2) inhibition with EPZ-6438 transdifferentiates mESCs into primitive endoderm stem cells. [Stem Cell Reports] Full ArticleGraphical Abstract