ARCN1 Suppresses Innate Immune Responses against Respiratory Syncytial Virus by Promoting STUB1-Mediated IKKε Degradation

Researchers demonstrated that archain 1 (ARCN1) suppresses the anti-Respiratory syncytial virus innate immune response by promoting E3 ubiquitin ligase STUB1-mediated K48-linked polyubiquitination and subsequent proteasomal degradation of IKKε.