Accelerated Cartilage Regeneration via Chondrocyte Metabolic Reprogramming Using Nano-Steroid-Conjugated Mesenchymal Stem Cells in Osteoarthritis

Scientists developed a novel therapeutic strategy by conjugating MSCs with steroid-loaded gold nanostars (MSC-Au-Steroid). The effects of MSC-Au-Steroid were assessed in vitro using osteoarthritis patient-derived chondrocytes and peripheral blood mononuclear cells, and in vivo using a monosodium iodoacetate-induced mouse model of osteoarthritis.