Pharmacological Inhibition of NF-κB in Mesenchymal Stromal Cells Selectively Partitions Apoptosis-Inducing Factors in Their Microvesicles and Proliferation-Inducing Factors in Their Exosomes: Implications in the Management of Acute Myeloid Leukemia

Researchers investigated whether NF-κB signaling pathway (NKI)-MSCs exert similar growth-inhibitory effects on leukemic cells. They found that both NKI-MSCs and their secretome induce cell cycle arrest in KG1a cells, a cell line of acute myeloid leukemia origin.