Newsletters

[JCI Insight] Researchers found expanded allogeneic Vδ2 T cells specifically eliminated HIV-infected CD4+ T cells and monocyte-derived macrophages, overcoming inherent resistance to killing by other cell types such as NK and CD8+ T cells.

[Science Translational Medicine] Researchers introduced a lipid nanoparticle platform that codelivers mRNA and the retinoic acid receptor agonist Am80, enabling antigen-specific mucosal immune responses in the gut via parenteral intramuscular vaccination.

[Nano Letters] The authors review the molecular and mechanistic principles underlying in vivo CAR-T cell therapy, emphasizing how these nanoscale design features govern CAR T cell production and functional performance in vivo.

[Nature Biomedical Engineering] Investigators generated knockout CAR T cells double deficient for the PGE2 receptors EP2 and EP4 by CRISPR–Cas9 engineering.

[Columbia University Irving Medical Center] Dr. Michel Sadelain has been awarded a BBVA Foundation Frontiers of Knowledge Prize in Biology and Biomedicine for revolutionizing cancer treatment with CAR-T cell therapy, which modifies a patient’s own T cells to seek and destroy cancer cells.

[Journal of the American Chemical Society] Scientists developed a prostate-specific lysosome-targeting degradation strategy using a prostate-specific membrane antigen (PSMA) as a lysosome-targeting receptor.

[Nature Communications] Scientists revealed significant sexual dimorphism in Tregs. Compared with hepatocellular carcinoma in female mice/patients, tumors in male mice/patients are more enriched in Tregs.

[Cancer Research] Investigators identified the purine biosynthesis intermediate succinylaminoimidazole carboxamide ribose-5′-phosphate (SAICAR) as a key metabolic driver of Treg induction and resistance to anti–PD-1 immunotherapy.

[Journal of Hematology & Oncology] Scientists highlight the differential redox sensitivities between tumor cells and key immune subsets. This differential sensitivity, where cytotoxic T cells are exhausted and immunosuppressive cells like Tregs thrive, is a fundamental mechanism of immune evasion.

[Signal Transduction and Targeted Therapy] The authors discuss several cellular processes, such as autophagy, endoplasmic reticulum stress, mitochondrial dysfunction, macrophage polarization, ferroptosis and the Th/Treg cell balance, which are associated with the occurrence and development of Ulceralive Colitis.

[Clinical and Experimental Medicine] Experimental validation researchers confirmed the significantly downregulation of BCAT2 in the lung tissues of IPF patients and in TGF-β1-treated alveolar epithelial cells

[Scientific Reports] Scientists investigated cold-inducible RNA-binding protein's function using an in vivo bleomycin-induced pulmonary fibrosis mouse model via intratracheal administration and an in vitro model with primary lung fibroblasts.