Newsletters

[Nature] Ferroptosis resistance of human T cells correlated with plasma lipid profiles across multiple healthy cohorts, exhibiting negative associations with polyunsaturated and monounsaturated fatty acids ratios in major lipid classes.

[Immunological Reviews] The authors integrate human studies with mechanistic models to map convergent pathways that connect pattern-recognition signaling, antigen presentation, and T- and B cell responses with monocyte and macrophage networks that drive injury, fibrosis, and electrical instability.

[Cancer Discovery] Researchers showed that elevated plasma IL-6 and C-reactive protein associate with increased tumor macrophage infiltration across multiple immune checkpoint blockade-treated cohorts.

[Signal Transduction and Targeted Therapy] Researchers identified a significant negative correlation between dendritic cell depletion and disease severity in patients with sepsis.

[Nature Communications] Scientists showed that recent Influenza B virus strains exhibit an enhanced ability to evade the innate immune response and an increased replication efficiency compared with earlier strains.

[npj Viruses] The authors characterized persistent upper respiratory tract pathology in SARS-CoV-2-infected hamsters.

[Cell Death & Disease] The authors recapitulate the proposed methods for cultivating organoids consisted of tumor cells and cancer-associated fibroblasts (CAFs) as well as molecular mechanisms involving in regulating variety of CAF subgroups.

[Cell Biology and Toxicology] Scientists explore the utility of brain organoids in environmental neurotoxicology, which address critical limitations of traditional models by recapitulating key aspects of human brain development, including 3D cytoarchitecture, multilineage cellular heterogeneity, and functional network activity.

[Development] Researchers provided the first comprehensive transcriptional profile of hiPSC-derived testis-like organoids.

[Iscience] To understand how different epithelial cell types and external stimuli shape the asymmetric secretion of immune regulators, researchers established and characterized a human intestinal organoid-on-chip model.

[Greenstone Biosciences (BioSpace)] Greenstone Biosciences announced a strategic collaboration with Neolaia Bio, who provide its proprietary drug candidates and discovery expertise, while Greenstone Biosciences will evaluate these compounds using hiPSC-derived macrophages and patient-relevant gut organoid models.

[Cell Stem Cell] Investigators introduced combined bone and lympho-myeloid bone marrow organoid (comBO), a scalable iPSC-derived system that generated osteolineage, vascular, lymphoid, and myeloid compartments within a single organoid.