Engineered CCR7 Overexpression Enhances Nodal CAR T-Cell Homing and Cytotoxicity toward B-Cell Lymphoma

Investigators showed that CAR T cells downregulated the chemokine receptor CCR7, crucial for nodal homing, during manufacturing. To improve nodal CAR T-cell trafficking, they engineered anti-CXCR5 CAR T cells, targeting mature lymphoma, with stable CCR7 expression.