IL-15 and IL-21 Synergy Improves Anti-Tumor Efficacy of iPSC-Derived Cytotoxic T Cells in Solid Tumors

Researchers engineered iPSC-derived cytotoxic T cells transduced with a CAR and identified an optimal cytokine armoring strategy. Co-expression of interleukin (IL)-15 and IL-21 synergistically enhanceds STAT1 phosphorylation, leading to increased transcriptional activation of the chemokine receptor CXCR3.