Newsletters

[Nature] Investigators developed human brain organoids for 5 years in culture, optimizing growth conditions to extend excitatory neuron viability beyond previous limits.

[Nature] Scientists demonstrated that, during Alzheimer’s disease progression in mice, astrocytes, and microglia increase phagocytic elimination of excitatory synapses while reducing elimination of inhibitory synapses.

[Nature Biomedical Engineering] Researchers defined the spatial and molecular determinants of malignant synapses by analysing intact human glioblastoma specimens, revealing enrichment of synapse-like structures and synapse-associated gene programmes at the tumor–brain interface.

[Cell Stem Cell] The authors developed an iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”). Single-nucleus RNA sequencing of miBrains confirmed the presence of diverse cell populations and revealed transcriptional responses to α-synuclein pathology.

[Neuron] Scientists developed the fluorescent bifunctional reporter neuro-seeER, “see estrogen response”, that can be used to track changes in estrogen dynamics in vitro and in vivo, including longitudinally in behaving animals.

[Science Advances] Researchers showed that local synthesis of Regenerating Family Member 3α, REG3A, in injured nerves activates translation of axonal KH-type splicing regulatory factor, Khsrp, mRNA in regenerating axons to slow peripheral nervous system nerve regeneration.

[Genes & Diseases] The authors investigated the effects of CUDC-907 on glioblastoma using cellular, organoid, and animal models to assess its inhibitory potential and toxicity.

[Biochimica Et Biophysica Acta-Reviews On Cancer] Investigators synthesize available literature on the role of the NGFR, particularly the p75 neurotrophin receptor, in glioblastoma progression.

[Yale School of Medicine] Yale School of Medicine received a grant of nearly $25 million from the Aligning Research to Impact Autism to map human brain development and investigate how and when autism diverges from typical development.

[International Journal of Oral Science] The authors elaborate on the regulatory roles and underlying molecular mechanisms of mechanical signals in key dentofacial developmental processes, including crown development, root morphogenesis, tooth eruption and replacement, as well as maxillomandibular bone development and remodeling.

[RCF] Rutledge Cancer Foundation (RCF) is advancing an ambitious new approach to Ewing sarcoma research through its $1.5 million ACES Grant, a three-year initiative bringing together leading researchers from John Hopkins and National Institutes of Health to pursue new treatment strategies.

[Cell Stem Cell] Scientists presented a stiffness-responsive MSC-assisted relayed tumor-targeting platform that converts matrix stiffness into a programmable molecular entry point for radiotheranostics.