Nuclear Focal Adhesion Kinase Induces APC/C Activator Protein CDH1-Mediated Cyclin-Dependent Kinase4/6 Degradation and Inhibits Melanoma Proliferation

The authors found that focal adhesion kinase (FAK) played a key role in cell cycle progression potentially through regulation of CDK4/6 protein expression and showed that FAK inhibition increased its nuclear localization and induced G1 arrest in B16F10 melanoma cells.