Modulation of PKM1/2 Levels by Steric Blocking Morpholinos Alters the Metabolic and Pluripotent State of Murine Pluripotent Stem Cells

Researchers investigated the role of pyruvate kinase muscle isoforms (PKM1/2) in naïve, formative, and primed mouse ESCs through modulation of PKM1/2 mRNA transcripts using steric blocking morpholinos that downregulate PKM2 and upregulate PKM1.