LAG3 Associates with TCR-CD3 Complexes and Suppresses Signaling by Driving Co-Receptor-Lck Dissociation

Scientists showed that LAG3 moved to the immunological synapse and associated with the T cell receptor (TCR)-CD3 complex in CD4+ and CD8+ T cells, in the absence of binding to major histocompatibility complex class II — its canonical ligand.