ADAM10 and ADAM17 Promote SARS-CoV-2 Cell Entry and Spike Protein-Mediated Lung Cell Fusion

Investigators identified the host metalloprotease ADAM17 as a facilitator of SARS-CoV-2 cell entry and the metalloprotease ADAM10 as a host factor required for lung cell syncytia formation, a hallmark of COVID-19 pathology.