Anti-PD-1 Chimeric Antigen Receptor T Cells Efficiently Target SIV-Infected CD4⁺ T Cells in Germinal Centers

The authors engineered an anti–PD-1 chimeric antigen receptor (CAR) to assess the impact of PD-1 depletion on viral reservoirs and rebound dynamics in SIVmac239–infected rhesus macaques