MiR-21 Regulates Epithelial–Mesenchymal Transition in Intestinal Fibrosis of Crohn’s Disease by Targeting PTEN/mTOR

Tissue biopsies from fibrotic and nonfibrotic intestine of Crohn’s disease (CD) patients, and non-CD patients were obtained; chronic intestinal fibrosis model established by TNBS was treated with antagonist of miR-21; human intestinal epithelial cell, NCM460, were transfected with miR-21 mimics or inhibitor.