MTG16 (CBFA2T3) Regulates Colonic Epithelial Differentiation, Colitis, and Tumorigenesis by Repressing E Protein Transcription Factors

Scientists identified MTG16 as a central mediator of epithelial differentiation, promoting goblet and restraining enteroendocrine cell development in homeostasis and enabling regeneration following dextran sulfate sodium-induced colitis.