Adipose Tissue-Derived Mesenchymal Stem Cells’ Acellular Product Extracellular Vesicles as a Potential Therapy for Crohn’s Disease

Considering the critical roles of macrophage polarization in Crohn’s disease and immunomodulatory properties of MSCs, the authors deciphered the interaction between adipose-derived MSCs and macrophages, including their cytokine production, regulation of differentiation, and pro-/anti-inflammatory function.